Ahdoot M, Wilbur AR, Reese SE, et al. - This study sought to present MRI-targeted, systematic, and combined biopsy for prostate cancer diagnosis. Researchers included a sum of 2,103 men who underwent both biopsy methods. Men with MRI-visible prostate lesions experienced both MRI-targeted and systematic biopsy. The primary endpoint included cancer detection according to grade group (i.e., clustering of Gleason grades). The detection of cancers of grade group 2 or higher and grade group 3 or higher, cancer detection stratified by previous biopsy status, and grade reclassification between biopsy and radical prostatectomy were considered the secondary endpoints. A combined biopsy led to more detection of all prostate cancers among individuals with MRI-visible lesions. Nevertheless, MRI-targeted biopsy alone underestimated the histologic grade of some tumors. The results of this study indicated that, after radical prostatectomy, upgrades to grade group 3 or higher on histopathological analysis were considerably lower after the combined biopsy.