Lorio S, Adler S, Gunny R, et al. - Researchers here assessed new diffusion models such as neurite orientation dispersion and density imaging (NODDI) and spherical mean technique (SMT) for computational and radiological characterization of focal cortical dysplasia (FCD) lesions compared with standard fractional anisotropy (FA) and mean diffusivity (MD). They calculated SMT, NODDI, FA, and MD maps for 33 pediatric patients with suspected FCD (18 histologically confirmed). Observations revealed more specificity of new diffusion maps of the intracellular volume fraction and per-axon mean, radial, and axial diffusivity to lesion changes than FA and MD. Across FCD histological subtypes in 18 patients, they noted different changes in intracellular volume fraction and per-axon mean, radial diffusivity maps. The new diffusion maps are thus suggested to have the potential to improve presurgical epilepsy MRI protocols by improving the characterization of FCD lesions.