Mankia K, et al. - Researchers performed hand MRI was performed in 93 cyclic citrullinated peptide (CCP)-positive at-risk persons (CCP +at risk) [47 early rheumatoid arthritis (RA) (ERA), 28 established ‘late’ RA (LRA) and 20 healthy controls (HC) and scored for interosseous tendon inflammation (ITI), flexor tenosynovitis (TSV) and RA MRI scoring at the metacarpophalangeal joints (MCPJs)] to study ITI in anti-CCP +at risk and also to elaborate the anatomy, prevalence and clinical relationships across the RA continuum. They noticed an incline in the proportion of subjects with ITI and the number of inflamed interosseous tendons (ITs) along the disease continuum ie, 19% of CCP +at risk, 49% of ERA and 57% of LRA had ≥1 IT inflamed. No ITI was discovered in HC. They observed no communication between the IT and the joint in the dye studies. They suggested ITs vital nonsynovial extracapsular targets in the development and progression of RA.