Xu Q, Xu Y, Sun H, et al. - Researchers herein sought for a non-invasive, reliable diagnostic tool for accurately evaluating complete tumor response to neoadjuvant therapy (NAT) in patients with locally advanced rectal cancer. Identification of several MRI-derived approaches has been done that are promising in predicting and recognizing complete tumor response. Although MRI plays a crucial role in both primary staging and restaging tumor response to NAT in rectal cancer, current MRI evaluation methods still have limitations. And hence, MRI alone cannot be completely depended on for the accurate evaluation of complete tumor response. In this work, some promising MR parameters in assessing complete response of rectal cancer were identified. And diagnostic performance may improve by the development of new techniques, such as MRI-derived textural analysis, radiomics analysis, and deep learning, which incorporate the clinical features which may help MRI become a non-invasive and reliable decision-making tool in examining complete response of rectal cancer.