Goorts B, et al. - This trial examined the correlation between magnetic resonance imaging (MRI)-based response patterns halfway through neoadjuvant chemotherapy and immunotherapy (NAC) and pathological tumor response in patients with breast cancer as well as to compare the predictive value of MRI-based response patterns measured halfway through NAC and after NAC and to measure interobserver variability. Results suggested that MRI-based response patterns halfway through NAC can predict pathologic response more precisely as compared to MRI-based response patterns after NAC. Complete radiological response halfway NAC was related to 83% pathological complete response (pCR), whereas complete radiological response after NAC seems to be correct in only 41% of cases.