Yuan Y, et al. - Via a retrospective study made of a training cohort (n = 85) and a validation cohort (n = 85) of patients with head and neck squamous cell carcinoma (HNSCC), the researchers intended to generate magnetic resonance imaging (MRI)-based radiomic signature and nomogram for preoperatively predicting prognosis in HNSCC patients. In patients with HNSCC, the radiomic signature that was made of 7 selected features from MR images, was markedly correlated with overall survival (OS). An independent association of the radiomic signature and TNM stage with OS of HNSCC patients was recognized, which were included to generate the radiomic nomogram. In comparison to the TNM stage only, the nomogram exhibited a better prognostic capability which was verified in the validation cohort. Hence, for HNSCC patients, an MRI-based radiomic signature was observed as an independent prognostic factor. Moreover, in clinical practice, nomograms based on the radiomic signature and TNM stage were exhibited as promising in the non-invasive and preoperative prediction of the prognosis of HNSCC patients.