Simeone FJ, et al. - In this IRB-approved and HIPAA-compliant study, investigators evaluated the group of 11 fungal discitis-osteomyelitis (FG) with MRI within 7 days of the biopsy and a control group (CG) of 19 Staphylococcus aureus discitis-osteomyelitis (DO) in order to contrast imaging and clinical features of fungal and Staphylococcus aureus DO for individuals presenting for CT-guided biopsies. Imaging findings (focal vs diffuse paravertebral soft tissue abnormality, partial vs complete involvement of the disc/endplate), biopsy location, pathology, duration of back pain, immune status, history of intravenous drug, history of the previous infection, up to date antibiotic treatment, and history of invasive intervention. Candida species were the most common fungal organisms. The FG was more inclined to had a focal soft tissue abnormality and partial disc/endplate involvement. It was found that MRI characteristics (focal partial soft tissue abnormality and partial involvement of the disc/endplate) in combination with clinical characteristics might help to prognosticate fungal species as a causative organism for DO.