Hu XX, et al. - In this retrospective review, researchers assessed the value of MR features based on Liver Imaging Reporting and Data System (LI-RADS ver.2017) to identify before surgery the status of cytokeratin (CK) 19 hepatocellular carcinoma (HCC) expression. The study sample consisted of 201 patients with 207 HCCs who underwent MR imaging. According to results, MR characteristics including targetoid appearance were observed more frequently while non-peripheral "washout" and non-rim arterial phase hyper-enhancement were found less frequently in CK19-positive HCCs vs CK19-negative HCCs. Serum alphafetoprotein (AFP)>20 ng/ml and targetoid appearance and non-peripheral “washout” were significant independent predictors of CK19-positive HCCs in multivariate analysis. Overall, the investigators concluded that targetoid appearance and absence of non-peripheral “washout” in combination with elevated AFP were useful to distinguish CK19-positive HCCs from CK19-negative HCC.