Siciliano M, et al. - The researchers aimed to evaluate fatigue in a consecutive sample of de novo Parkinson's disease (PD) patients and to systematically search for the motor, behavioural, and cognitive correlates of distressing fatigue. Distressing fatigue was correlated with episodic anxiety, cognitive apathy, and sleepiness, but not with cognitive impairment in a sample of consecutive de novo PD patients. The findings proposed possible shared pathogenic mechanisms underlying these non-motor symptoms and encouraged the development of early combined therapeutic approaches.