Deng L, et al. - Researchers compared patients diagnosed with lung cancer as a second primary malignancy (lung-2) to those with lung cancer as the first primary malignancy (lung-1), in terms of overall and cancer-specific survival. From the Surveillance, Epidemiology, and End Results (SEER) program, primary lung cancer patients diagnosed from 1988 to 2014 were selected. They identified 679,541 and 85,758 patients as lung-1 and lung-2, respectively. In the first 5 years, a lower risk of lung cancer-specific mortality was observed in lung-2 patients, however, these patients had a higher risk thereafter, independent of tumor features and cancer therapy. They found similar pattern for overall mortality, although the survival benefit was limited to the first year post-diagnosis. In this study, no support was offered to a conservative approach to manage lung-2 solely based on malignancy history.