Monahan RC, Fronczek R, Eikenboom J, et al. - In patients with systemic lupus erythematosus (SLE) and neuropsychiatric (NP) symptoms in the Netherlands between 2007–2018, researchers conducted this retrospective analysis to assess all-cause and cause-specific mortality. The sample consisted of patients (n = 351) attending the tertiary referral NPSLE clinic of the Leiden University Medical Center. NP symptoms were linked to SLE requiring treatment (major NPSLE) or to other and mild causes (minor/non-NPSLE). One hundred forty-nine patients were classified as major NPSLE (42.5%) out of 351. Cause-specific mortality rates showed an increased risk of death due to infections in both groups, while death due to cardiovascular disease was only higher in minor/non-NPSLE patients. In contrast to the general population, mortality was increased in both major NPSLE and minor/non-NPSLE patients. There was no mortality difference between patients with major NPSLE and minor/non-NPSLE.