Mortality in patients undergoing revascularization with paclitaxel eluting devices for infrainguinal peripheral artery disease: Insights from a network meta‐analysis of randomized trials
Catheterization and Cardiovascular Interventions Jul 26, 2020
Kuno T, Ueyama H, Mikami T, et al. - Via network meta‐analyses, researchers investigated if paclitaxel eluting devices raised mortality risk in patients receiving revascularization for infrainguinal peripheral artery disease. They identified randomized trials with patients with infrainguinal peripheral artery disease who had revascularization with or without a paclitaxel eluting device (balloon/stent), by exploring PUBMED and EMBASE through April 2020. This study involved 57 eligible randomized controlled studies with 9,362 patients. Seven revascularization strategies (balloon angioplasty vs bare metal stent vs covered stent vs paclitaxel eluting stent vs other drug eluting stent vs paclitaxel‐coated balloon vs bypass surgery) were compared in these studies. Findings revealed that the use of paclitaxel eluting stent was not related to a significant increase in mortality, but paclitaxel‐coated balloon was related to increased risk of long‐term death when used in the treatment of infrainguinal peripheral artery disease.
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