Cruz RS, et al. - Researchers analyzed 21 studies to determine the impact of age on mortality in elderly subjects on mechanical ventilation. Eligible studies compared two different age groups. Mortality in subjects ages ≥ 65 years was considered the primary outcome, and the secondary outcomes included severity scores, intensive care unit and hospital lengths of stay, and the presence of ventilator-associated pneumonia. Via subgroup analysis, subjects with ARDS and of cutoff ages of 70 and 80 years were examined for mortality. Despite low-quality evidence, the investigators concluded that age may be associated with greater mortality in critically ill subjects receiving mechanical ventilation.