Golpe R, et al. - COPD patients classified in accordance to the Spanish COPD guidelines were investigated to assess if the mortality rates were different between four predefined clinical phenotypes [asthma–COPD overlap (ACO; 75 subjects), nonexacerbator (NONEX; 531 subjects), exacerbator with chronic bronchitis (EXCB; 194 subjects), and exacerbator with emphysema (EXEMPH; 91 subjects)]. As per findings, this classification of COPD patients can identify clusters of subjects with different mortality outcomes. The ACO phenotype showed the best long-term prognosis, whereas EXEMPH showed the highest risk of death. Findings also indicated some differences in the causes of death, and patients with EXEMPH were at a higher risk of dying because of COPD itself.