Moskowitz CS, Chou JF, Neglia JP, et al. - Female participants in the Childhood Cancer Survivor Study—a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 prior to the age 21 years, and subsequently diagnosed with breast cancer (n = 274)—were enrolled in this study by the researchers in order to define the ensuing risk for mortality and additional breast cancers. The investigators found that breast cancer–specific mortality was moderately increased among childhood cancer survivors; survivors were five times more likely to die due to other health-related causes, like other following malignant neoplasms and cardiovascular or pulmonary disease. Thus, mortality following breast cancer was greater in childhood cancer survivors vs in women with de novo breast cancer. This progressed mortality highlights the burden of comorbidity and reflects the requirement for risk-decreasing interventions.