Eich ML, Pena MDCR, Schwartz L, et al. - A retrospective multi-institutional database search was conducted to assess the pathologic features and clinical outcomes in cases of invasive penile squamous cell carcinoma (SCC) and the association with p16 immunohistochemistry (IHC) and human papillomavirus (HPV) in situ hybridization (ISH). Pathologic features, p16 IHC, and HPV ISH were investigated with clinical outcomes. Researchers recruited a sum of 102 individuals. Between 2007 and 2018, this research was carried out for invasive SCC of the penis diagnosed that had undergone surgical resection. It is indicated that HPV is a common cause of penile SCC and can be diagnosed by tumor histology and confirmed by the overexpression of p16 on IHC. The results of this study indicated that the presence of lymphovascular invasion, perineural invasion, and urethral involvement are poor prognostic indicators, whereas HPV-related tumors based on histology may have a lower risk for metastatic disease.