Tanimura K, Otake H, Kawamori H, et al. - This study sought to present morphological plaque characteristics and clinical outcomes in patients with acute coronary syndrome and cancer history. Researchers designed a retrospective, multicenter, observational cohort study that included consecutive patients with acute coronary syndrome (ACS) who had undergone optical coherence tomography‐guided emergent percutaneous coronary intervention. Individuals were classified into those without a cancer history, those with a cancer history, and those currently receiving cancer treatment. They categorized ACS culprit lesions into plaque rupture, plaque erosion, or calcified nodule using optical coherence tomography. The findings demonstrated that individuals with a cancer history had significantly worse clinical outcomes after ACS than those without a cancer history. According to the findings, those with a cancer history had significantly higher plaque erosion and calcified nodule incidences in the ACS culprit lesions, which might partly explain their worse clinical outcomes.