Maruyama Y, Ikeda Y, Mori, et al. - Researchers conducted this observational study to examine the time-dependent change of corneal endothelial cell (CEC) morphology and density (CECD) in individuals with glaucoma post instillation of rho-associated protein kinase inhibitor ripasudil (Rip) 0.4% eye drops. The sample consisted of 163 patients (163 eyes) with glaucoma in whom CEC morphological change was assessed by CECD calculated via noncontact specular microscopy (NCSM) before and at 1 or 3 months post-Rip instillation. The NCSM software provided misleading data for CECD determination within 1 hour after Rip instillation due to transient morphological changes, but showed that CEC morphology gradually recovered to normal within 6 hours.