Sanati S - The morphologic features, prognostic biomarkers, and molecular features of ductal carcinoma in situ (DCIS) were reviewed in this manuscript. Estrogen and progesterone receptors are the established biomarkers in clinical decision making. Also, a number of biomarkers like HER2, p53 tumor suppressor gene, ki67 proliferation marker, and tumor infiltrating lymphocytes have proven to be of prognostic importance. DCIS has different molecular alterations at the low and high-grade molecular level and the intrinsic molecular subtypes in invasive carcinoma also exist in DCIS with prognostic implications.