Eguiluz-Gracia I, et al. - Since a rapid accumulation of activated monocytes in the nasal mucosa resulting in recruitment of T-helper type 2 (Th2) cells and eosinophils after local allergen challenge has been recently seen in an experimental human model of allergic rhinitis (AR), researchers investigated if monocytes are recruited to the lungs in paediatric asthma. They obtained tissue samples from children and adolescents with fatal asthma attack (n=12), age-matched non-atopic controls (n=9), and allergen-challenged AR patients (n=8). These samples were subjected to in situ immunostaining. According to findings, the accumulation of monocytes was evident in the lungs of children and adolescents with fatal asthma attack. This strongly pointed to a direct involvement of monocytes in the immunopathology of asthma and suggested that these proinflammatory cells are potential targets for therapy.