Basile D, et al. - In this retrospective cohort study, researchers assessed the prognostic impact of monocyte-to-lymphocyte ratio (MLR) and LDH levels on overall survival (OS) in patients with metastatic colorectal cancer (mCRC) by using uni- and multivariate Cox regression analysis. They analyzed consecutive data of 165 patients with mCRC treated 2004-2017 at the Unit of Medical Oncology and Oncology Prevention, CRO of Aviano. A median OS of 30.74 months was observed at a median follow-up of 61.87 months. Resection, metastasectomy, and sidedness were found to be related to better OS in univariate analysis. Conversely, factors that were identified to be related to worse OS included older age, KRAS mutation, LDH or MLR high or both. In this patient population, high baseline LDH, MLR or both were identified as poor prognostic factors, which further supports the interlink between immune system, inflammation, and cancer.