Scala E, et al. – This study strived to analyse the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR–10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1). Peculiar relationships between clinical phenotypes and sensitization profiles were unveiled by testing IgE reactivity to a panel of PR–10s in a birch–free area. It permitted the identification of novel cluster patterns.