Lee MC, Hsiao TH, Chuang HN, et al. - Molecular profiling on the basis of RNA-sequencing (RNA-seq) for myasthenia gravis development in individuals with thymoma (n = 140) was examined in order to recognize precise and efficient molecular markers for prognosticating in the development of myasthenia gravis people with thymoma. In cases with thymoma who has myasthenia gravis, the four genes, hypoxia-inducible factor 3 alpha (HIF3A), insulin-like growth factor-binding protein 1, pyruvate dehydrogenase kinase, and Krüppel-like factor 15 were differentially expressed and were confirmed by a quantitative polymerase chain reaction. In individuals with myasthenia gravis, compared with those without, HIF3A expression was notably higher. Thus, in the individuals with thymoma who has myasthenia gravis HIF3A is aberrantly expressed and could be included in the development of myasthenia gravis in thymoma person.