Ooft M, et al. - A scrutiny was conducted of the differences in methylation profiles, and thus pathogenesis, between Epstein-Barr virus (EBV)-positive and negative nasopharyngeal carcinomas (NPCs). The results unveiled vital epigenetic variations between EBV-negative and EBV-positive NPCs. EBV-negative NPC displayed a more similar hypermethylation profile to other head and neck squamous cell carcinomas than EBV-positive NPC. Hypermethylation of RASSF1A could contribute to worse overall survival (OS) in EBV-positive NPC. This could, thereby, serve as a notable event in the pathogenesis of EBV-infected NPC. Hypermethylation of APC could cause worse DFS in EBV-negative NPC.