Kundel Y, et al. - Researchers investigated if the expression of specific molecular markers in the rectal cancer biopsies prior to treatment can correlate with complete tumor response to chemoradiotherapy (CRT) as determined by the pathology of the surgical specimen. They carried out a retrospective analysis of patients (aged 18 years or older) who had undergone neoadjuvant CRT and surgical resection for locally advanced rectal cancer in their tertiary-care, university-affiliated medical center, between January 2001 and December 2011. They found that patients who will benefit from neoadjuvant CRT can be identified with the help of epidermal growth factor receptor expression pattern in the pretreatment biopsies of rectal tumors.