Inage T, et al. - Researchers investigated a highly sensitive molecular biomarker for lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). They performed a microRNA (miRNA) expression analysis wherein 5 miRNAs (miR-200a, miR-200b, miR-200c, miR-141, and let-7e) were selected as biomarker candidates for the detection of nodal metastasis. For each marker, they established a cutoff level of expression to differentiate malignant from benign lymph nodes. Thereafter, they applied the cutoff level to snap-frozen EBUS-TBNA samples. They also analyzed archived formalin-fixed paraffin- embedded (FFPE) samples rebiopsied by EBUS-TBNA after induction chemoradiotherapy. Findings revealed miR-200c showed high sensitivity as a molecular staging biomarker and could potentially enhance nodal staging of lung cancer.