Samala N, et al. – In this overview, the authors present the role of 12–Lipoxygenase in nonalcoholic fatty liver disease pathogenesis and its potential role in emerging new therapeutics. As insulin resistance is closely correlated with establishment of nonalcoholic fatty liver disease, the role of 12–Lipoxygenase in pathogenesis of nonalcoholic fatty liver disease has received increasing attention in current years.