Al-Rawaf HA, Alghadir AH, Gabr SA., et al. - Among 150 older adults (aged 65.4 ± 3.7 years) with mild cognitive impairment (MCI), researchers sought to assess the potential role of circulated miRNAs in the pathogenesis of MCI and its correlation with cellular oxidative stress, apoptosis, and circulated BDNF, 1 (SIRT1, and dipeptidyl peptidase-4 (DPP4). Study participants were classified into a healthy normal (n = 80) group and an MCI (n = 70) group. In the serum of MCI patients, the levels of miR-124a and miR-483-5p increased significantly and miR-142-3p and miR-125b decreased significantly vs controls. Circulating miR-124a, miR-483-5p, miR-142-3p, and miR-125b were significantly linked to severe cognitive decline, cellular oxidative stress, and apoptosis in MCI patients, and could therefore be potential non-invasive biomarkers for the diagnosis of MCI with high diagnostic performance.