Roemer FW, et al. - Authors ascertained the role of inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury to predict radiographic knee osteoarthritis (OA) and magnetic resonance imaging (MRI)–defined knee OA at 5 years postinjury. They also assessed the concordance of inflammatory biomarkers assessed by MRI and synovial fluid (SF) analysis. ROA or MROA at 5 years postinjury was neither predicted by MRI-detected inflammation nor selected SF/serum inflammation biomarkers at 2 years postinjury. They noted weak concordance between MRI and SF inflammatory biomarkers.