Breis LC, Schlindwein MAM, Bandeira IP, et al. - A systematic review was conducted to evaluate the possible relationships between myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) and systemic Lupus Erythematosus (SLE) based on reported features found in the literature that support the association of the two. Researchers performed a keyword-based literature search, applying a ten-year filter and utilizing the following key-words: “MOG autoantibody-associated disease and Systemic Lupus Erythematosus”; “MOG and Systemic Lupus Erythematosus” “Anti-MOG and Lupus”; “MOG and SLE”; “MOG and LUPUS” on MEDLINE/PUBMED, ScienceDirect, SciELO, LILACS and Cochrane; and “MOG antibody-associated disease and SLE” on Google Scholar. As per the findings, not much is known about the connection between MOG-IgG-associated disorder and SLE. In humans, only observational studies have been conducted so far, providing us with limited data. This is not a universal finding, while MOGAD features have been reported to develop in SLE patients. The outcomes suggested that many different issues impair these outcomes, making it difficult to match the findings of different trials.