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Modifying effect of statins on fatal outcomes in chronic kidney disease patients in the Systolic Blood Pressure Intervention Trial: A post hoc analysis

American Journal of Nephrology Apr 01, 2019

Rivera M, et al. - Among chronic kidney disease (CKD) patients participating in a clinical trial, researchers assessed the modifying impact of statins on the association of systolic blood pressure (SBP) goal with mortality and other outcomes in this observational study. Randomization of 2,646 CKD patients (estimated glomerular filtration rate < 60 mL/min/1.73 m2) to an intensive SBP goal < 120 mm Hg or standard SBP goal <140 mm Hg was done at baseline. A total of 1,273 patients were not receiving statin and 1,354 were receiving statin. The use of statin was unknown in 19. Following adjusting for age, gender, race, cardiovascular disease (CVD) history, smoking, aspirin use, and blood pressure at baseline, statin use modified the associations of SBP goal with all-cause mortality and cardiovascular (CV) mortality. Hypertensive patients with CKD showed improved survival when received statin therapy together with intensive SBP management.
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