Yandrapalli S, et al. - In 1,462,168 young adults with a first acute myocardial infarction (AMI) (mean age 50 ± 7 years, 71.5% men, 58.3% white) identified from the U.S. National Inpatient Sample years 2005 and 2015, researchers investigated the prevalence rates of modifiable risk factors (RFs) during a first AMI, sex/race differences, and temporal trends in this retrospective cohort analysis. They identified smoking (56.8%), dyslipidemia (51.7%), and hypertension (49.8%) constituted the most prevalent risk factors in the 18- to 44-year group, and 90.3% of patients had at least 1 RF. The most prevalent in the 45- to 59-year group were hypertension (59.8%), dyslipidemia (57.5%), and smoking (51.9%), and 92% patients had at least 1 RF. A high prevalence of modifiable RFs, which progressively increased over time, was seen during a first AMI in young adults in whom preventive measures were more likely to be effective. For individual RFs, they noted marked sex and racial differences. The prevalence of diabetes mellitus, hypertension, and obesity was higher among women, and men demonstrated a higher prevalence of dyslipidemia, drug abuse, and smoking.