Cornish AJ, Law PJ, Timofeeva M, et al. - Researchers investigated how 39 potentially modifiable risk factors are associated with colorectal cancer in 26,397 patients with colorectal cancer and 41,481 controls (ie, people without colorectal cancer). They derived these population data from a genome-wide association study of people of European ancestry, which was revised to exclude UK BioBank data. After correction for multiple testing, no putative risk factors were identified to have a significant association with colorectal cancer risk. However, the increased risk seemed to be associated with genetically predicted body fat percentage, body-mass index, waist circumference, basal metabolic rate, and concentrations of LDL cholesterol, total cholesterol, circulating serum iron, and serum vitamin B12, although potential pleiotropy among genetic variants used as instruments for vitamin B12 constrains the finding. Further, the association was suggested between adult height and increased risk of colorectal cancer and between low blood selenium concentration and decreased risk of colorectal cancer.