Byun DJ, Katz LM, Xiao J, et al. - Given that good disease control and toxicity outcomes may be obtained with neoadjuvant chemoradiation (NA-CRT) followed by resection of high-risk soft tissue sarcoma (STS), therefore, herein researchers describe a single institution’s modern NA-CRT experience. They analyzed 37 consecutive cases of localized high-risk STS. Of these, 29 were managed with ifosfamide-based NA-CRT to a median dose of 50 Gy prior to en bloc resection. A median follow-up of 40.3 months was performed. The 5-year overall survival, disease-free survival, distant metastasis-free survival, and local control (LC) were estimated to be 86.1%, 70.2%, 75.2%, and 86.7%, respectively. Overall, favorable disease control was revealed in this single-institution series of NA-CRT. Inferior LC was noted in relation to delay in surgical resection, this observation needs further evaluation in a larger cohort.