Chooi YC, et al. - The goal of this study was to scrutinize the effects of diet-induced 5% weight loss on body composition and metabolic function in metabolically obese normal weight (MONW) subjects. An estimation was performed of the total body fat, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) volumes, intrahepatic and intramyocellular lipid contents, insulin sensitivity (hyperinsulinemic-euglycemic clamp), glucose tolerance, and postprandial insulin secretion and clearance rates (mixed meal with minimal modeling). It was observed that weight loss decreased total fat mass by ∼9%, VAT and SAT volumes by ∼11% and ∼17%, respectively, and intrahepatic fat by ∼50%. Findings illustrated that diet-induced moderate weight loss improved the body composition, lipid profile, and insulin sensitivity and thereby reduces cardiometabolic risk in MONW Asians.