López-Padilla D, Terán-Tinedo J, Cerezo-Lajas A, et al. - Based on the findings of this study, experts recommend not prescribing continuous positive airway pressure (CPAP) to decrease cardiovascular events (CVE) likelihood in older adults suffering from moderate obstructive sleep apnea (OSA).

• This observational, multicentric study included 614 older adults with moderate OSA.

• Two groups were defined: (1) CPAP treatment and (2) standard of care.

• Primary and secondary endpoints were assessed in 236 participants, post-matching.

• At least one CVE (17.4%) occurred in 41 patients; 20 were in the standard of care group (16.9%) and 21 were in the CPAP group (17.8%) with relative risk of 1.05 for CPAP treatment.

• Adjusted relative risk for CPAP treatment was 1.24, by inverse probability weighting of the initial 614 patients.

• There were no statistical differences in secondary endpoint (incidence of CVE separately and time to first CVE) analyses.