Eiro N, Cid S, Fernández B, et al. - Through a study of 246 women with invasive breast carcinoma and with a long follow-up period, researchers intended to suggest the assessment of MMP11 expression by intratumoral mononuclear inflammatory cells (MICs) as a beneficial biological marker for breast cancer prognosis. Relative to nodal status and to the development of the metastatic disease, individuals were stratified. In individuals without metastasis and in individuals with metastatic disease, the median follow-up period was of 146 months and 31 months, respectively. MMP11 was ascertained via immunohistochemistry. MMP11 expression by stromal cells attained a notable correlation with prognosis. MMP11 expression by cancer-related fibroblasts was correlated with both shortened relapse-free survival (RFS) and overall survival (OS) but MMP11 expression by MICs attained a stronger correlation with both shortened RFS and OS being the most efficient and independent factor to prognosticate RFS and OS.