Fouda UM, et al. - This study aimed at determining the effectiveness of vaginal misoprostol in minimizing the pain perceived by patients with no risk factors for cervical stenosis (i.e., parous women of reproductive age who have no history of cesarean section or cervical surgery) during diagnostic office hysteroscopy. In the subgroup of patients with no risk factors for cervical stenosis, findings revealed no beneficial role of misoprostol administration prior to diagnostic office hysteroscopy.