Mismatch repair–deficient colorectal cancer: A model of immunogenic and immune cell–rich tumor despite nonsignificant PD-L1 expression in tumor cells
Human Pathology Dec 07, 2017
Le Flahec G, et al. - Programmed cell death ligand-1 (PD-L1) expression and the tumor immune microenvironment in mismatch repair–deficient (dMMR) colorectal cancer (CRC) was developed as a model of good responders to immunotherapy. The value of PD-L1 testing to accompany the development of anti–PD-1/PD-L1 immunotherapy was unclear as a result of the poor association with mismatch repair status and technical limitations.
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