Mor A, Gardezi M, Jubanyik K, et al. - Researchers conducted a prospective cohort study with the aim to determine if high alpha-fetoprotein (AFP) level in vaginal blood obtained on a sanitary pad can allow detection of an active miscarriage. Evaluation of five groups was performed: women with active miscarriage, pregnancy of unknown location, completed miscarriage or extrauterine pregnancy (EUP), ongoing pregnancy, and undergoing elective dilation and curettage (D&C). In the active miscarriage (n = 16) and the elective D&C (n = 24) groups, the vaginal blood AFP median levels (and their ranges) of 3.7 IU/mL (0.5–739.2) and 4,542 IU/mL (15.6–100,000), respectively, were observed. Observations suggest that extraction of alpha-fetoprotein can be done in vaginal blood collected on sanitary pads. A high level of vaginal AFP can assist with the same-day identification of an active miscarriage. This novel test is identified as valuable in distinguishing active miscarriages from ongoing pregnancies, completed miscarriages, and EUPs and, hence, it decreases uncertainty, anxiety level, and number of repeat office visits.