Wu C, et al. – The objectives of this study are to identify cataract regulated miRNA target genes that are identified with oxidative stress and to propose a new possible mechanism for cataract formation. They suggest for the first time a hypothesis that cataract regulated miRNAs could contribute to cataract formation not only by targeting 3' UTR but also by targeting TATA–box region of oxidative stress related genes. These outcomes in the subsequent elevation of pro–oxidative genes and inhibition of anti–oxidative genes. This miRNA–TATA–box/3' UTR–gene–regulation network may contribute to cataract pathogenesis.