Liu F, et al. - Because miR-935 had been proved to be an oncogene or tumor suppressor in many cancers, researchers focused on the role of miR-935 in RCC (renal cell carcinoma). To verify miR-935 expression, they utilized real-time quantitative polymerase chain reaction (qRT-PCR). They determined the cell proliferation, migration and invasion of miR-935 by using CCK-8 assay, wound healing assay and transwell assay. They found that RCC cells and cancer tissues exhibited a higher expression level of miR-935. MiR-935 copied promoted cell proliferation, migration and invasion, and cell inhibit malignancy of cancer cells was inhibited by miR-935 inhibitor. Iron-responsive element-binding protein 2 (IREB2) was found as a direct target of miR-935, in bioinformatics analysis and dual-luciferase reporter assay. Downregulation of IREB2 expression in clear cell renal cell carcinoma (ccRCC) cancer tissues was revealed by qRT-PCR, and longer overall survival and disease-free survival was observed in relation to high IREB2 expression. The possible action of miR-935 as an oncomiRNA was suggested, as well as its impact on migration and invasion promotion of ccRCC by targeting IREB2. The possibility of oncogene miR-935 being a molecular marker was suggested, and it may unveil novel strategies for ccRCC.