Chen S, Zhang J, Sun L, et al. - Researchers conducted this investigation to examine the impacts of miR-611 on tongue squamous cell carcinoma (TSCC) and the underlying mechanism. Using quantitative reverse transcriptase-polymerase chain reaction, the expression level of miR-611 in TSCC tissues was measured. By performing CCK-8, IncuCyte, and Transwell assays, cell proliferation, migration, and invasion were examined. To evaluate the impacts of miR-611 in vivo, the xenograft model has been used. According to results, miR-611 was upregulated in TSCC tissues that were significantly correlated with TNM stage and negatively related to overall patient survival. Furthermore, miR-611 upregulation not only potentiated the proliferation, migration, invasion, and epithelial–mesenchymal transition of TSCC cells in vitro, but also encouraged tumour growth in vivo. FOXN3 has been identified and subsequently verified as a miR-611 candidate target gene. Lastly, miR-611 induced a malignant TSCC phenotype rescued by FOXN3 overexpression. Overall, the authors concluded that miR-611 is a novel TSCC therapeutic target.