Gurm HS, et al. - In this multicenter, single-arm, observational study of patients undergoing diagnostic coronary angiogram (CAG) and/or percutaneous coronary interventional (PCI) procedures performed with manual injections, researchers assessed contrast media (CM) volume (CMV) saved using the DyeVert Plus Contrast Reduction System (DyeVert Plus System, Osprey Medical). As per the eligibility criteria, participants were required to be ≥ 18 years old with baseline estimated glomerular filtration rate (eGFR) 20–60 mL/min/1.73 m². Overall 114 subjects with mean age 72 ± 9 years, and mean body mass index of 29 ± 5 were included, 72% were male. Baseline eGFR was 43 ± 11 mL/min/1.73 m². Evaluable patients were 105. Mean CMV attempted and mean CMV delivered was 112 ± 85 mL (range 22–681) and 67 ± 51 mL (range 12–403), respectively, with an overall CMV savings of 40.1 ± 8.8% per procedure. They found no DyeVert Plus System-related adverse events. In chronic kidney disease patients undergoing CAG and/or PCI, clinically meaningful CMV savings with maintained image quality can be achieved with the use of DyeVert Plus System.