Araki K, Tomifuji M, Shiotani A, et al. - This multicenter trial was undertaken to determine if the combination of minimally invasive transoral surgery (TOS) with sentinel node navigation surgery using indocyanine green (ICG-SNNS) can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This investigation was conducted in Japan. Participants in the study were 22 patients with clinical T1 or T2, N0 oropharyngeal, hypopharyngeal, or supraglottic cancer. Data reported that the rate of identification was 100%. It was noted that the precision was 95.5%, sensitivity was 75%, and specificity was 100%. Results revealed that the disease-specific survival for 5 years was 100%, overall survival was 72.3%, and disease-free survival was 60.5%. Findings suggested that the combination of TOS with ICG-SNNS is feasible as a minimally invasive strategy and has beneficial oncological results.