Misono S, et al. - This trial intended to utilize an anchor-based approach for measuring the minimal important difference (MID) in the Voice Handicap Index–10 (VHI-10) total score. A variation of 6 on the VHI-10 possibly reflected MID. A correlation existed between such variation with a moderate change on the global rating scale. It was discovered that the small-change and no-change categories were indistinguishable. Owing to the paucity of differentiation between small and no change and the modest link between the global change score and change in the VHI-10 score, advanced research was necessitated.