Ampuero J, et al. – Researchers planned this study to evaluate whether minimal hepatic encephalopathy (MHE) could be a surrogate marker of a further liver disease. They concluded that MHE was correlated with cirrhosis progression and demonstrated a higher cumulative and annual incidence rate of disease progression. Irrespective of cirrhosis status, MHE could be a surrogate marker of disease progression, identifying patients at risk of suffering a more aggressive cirrhosis form.