Hung CI, et al. - The associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD) were investigated. Based on the International Classification of Headache Disorders, researchers diagnosed migraines. They also used the bodily pain subscale of the Short Form 36 and the pain subscale of the Depression and Somatic Symptoms scale. The longitudinal impacts of migraine on pain symptoms was assessed using Generalized Estimating Equation models. During long-term follow-up, migraine was identified as an important comorbidity associated with a greater severity of pain symptoms. Researcher suggest integrating migraine treatment into the treatment of depression to improve pain symptoms and quality of life in the pain dimension.