Chu JC, Devall AJ, Beeson LE, et al. - Via performing MifeMiso, a multicentre, double-blind, placebo-controlled, randomized trial, in 28 UK hospitals, researchers examined rate of completion of missed miscarriage in correlation with treatment with mifepristone plus misoprostol vs misoprostol alone. They randomly assigned 711 women, who were diagnosed with a missed miscarriage by pelvic ultrasound scan in the first 14 weeks of pregnancy and chose to have medical management of miscarriage, to receive a single dose of oral mifepristone 200 mg or an oral placebo tablet. Both of these groups received a single dose of vaginal, oral, or sublingual misoprostol 800 μg 2 days later. Outcomes suggest higher effectiveness of treatment with mifepristone plus misoprostol vs misoprostol alone in the management of missed miscarriage. They support offering mifepristone pretreatment before misoprostol to women with missed miscarriage for improving the chance of successful miscarriage management, while decreasing the necessity for miscarriage surgery.