Chu JJ, Devall AJ, Beeson LE, et al. - Researchers examined the rate of completion of missed miscarriage in correlation with treatment with mifepristone plus misoprostol vs misoprostol alone. They conducted a multicentre, double-blind, placebo-controlled, randomized trial, named MifeMiso, in 28 UK hospitals including 711 women. Of these women, 357 were randomly assigned to receive mifepristone and misoprostol and 354 to receive placebo and misoprostol. Outcomes suggest superior effectiveness of treatment with mifepristone plus misoprostol vs misoprostol alone in the management of missed miscarriage. They emphasize offering mifepristone pretreatment before misoprostol to women with missed miscarriage to improve the chance of successful miscarriage management, while lowering the necessity for miscarriage surgery.